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The standard cagrilintide monotherapy titration follows this schedule: 0.25 mg weekly for weeks 1-4, then 0.5 mg for weeks 5-8, then 1.0 mg for weeks 9-12, then 1.7 mg for weeks 13-16, and finally 2.4 mg for week 17 onward as the maintenance dose

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The spherical architecture of the MB combined with the cellularly degradable eECM creates a distinct niche that promotes cell viability and maintenance of the secretory acinar cells based on gene and protein expression as well as secretory function based on tissue architecture, gene expression, and secretory agonist-responsive calcium signaling 17